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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Bone marrow-derived neural crest precursors improve nerve defect repair partially through secreted trophic factors

Fig. 5

Histology and morphology observation of hindlimb muscles. a Histograms showing the difference of wet weight ratio of targeted muscles (injured side/contralateral uninjured side) among the non-grafted group and 3 grafted groups. n = 8; #p < 0.05, ###p < 0.001 compared with the autograft group, §p < 0.05, §§p < 0.01, §§§p < 0.001 compared with the non-grafted group. b Histograms showing the cross-sectional area of muscle fiber and the average percentage of collagen fiber area of gastrocnemius muscle and tibialis anterior muscle in uninjured, autograft, TENG, conduit, and non-grafted groups (see also Additional file 2: Figure S1A). n = 4; ***p < 001 compared with the uninjured group; #p < 0.05, ##p < 0.01, ###p < 0.001 compared with the autograft group; p < 0.05, p < 0.001 compared with the conduit group; §§§p < 0.001 compared with the non-grafted group. c Representative images of Masson trichrome staining of cross-sectional gastrocnemius muscle in uninjured, autograft, TENG, conduit, and non-grafted groups. Scale bar, 50 μm. d Representative images of cholinesterase histochemistry staining for motor endplates of longitudinal gastrocnemius muscle section in uninjured, autograft, TENG, conduit, and non-grafted groups. Scale bar, 50 μm. e Representative TEM images of muscle segment morphology of gastrocnemius muscle in uninjured, autograft, TENG, conduit, and non-grafted groups. Scale bar, 2 μm

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