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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their progeny past the pluripotency stage

Fig. 3

Differentiation and reprogramming of ESCs harboring the developed Oct4 tracing system in comparison with OG2 reporter system. a Onset of the tdTomato expression on day 6 due course of iPSC colony formation following Dox/4-OHT treatment and infection of the O4S ESC-derived neural stem cells (NSCs) with the OKSM lentivirus. b Retention of tdTomato signal in differentiated cells derived from O4S ESCs. c Loss of GFP signal in differentiated cells derived from OG2 ESCs. d Schematic comparison of O4S system with two other common types of systems aimed to study Oct4 activity

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