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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

Fig. 5

HLA-ABC expression in IFNγ + IL-1β- and IFNα-exposed iPSC-derived pancreatic endocrine cells. Control iPSCs (HEL115.6) were differentiated into pancreatic endocrine cells and exposed to IFNγ + IL-1β or IFNα. Cells were fixed, and expression of insulin (Ins), glucagon (Gcg) and HLA-ABC was evaluated (Ins green, HLA-ABC red, Gcg far red). Nuclei were counterstained with DAPI. Pictures were taken with a fluorescence microscope with × 20 magnification (scale bar = 50 μm) and are representative of six independent experiments

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Stem Cell Research & Therapy

ISSN: 1757-6512