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Table 3 Average chemiluminescent signal intensities

From: Reproducibility of GMP-compliant production of therapeutic stressed peripheral blood mononuclear cell-derived secretomes, a novel class of biological medicinal products

Analyte

PBMCsec (mean gray values)

Placebo (mean gray values)

Apolipoprotein A-I

163 ± 24

11 ± 0

BAFF

161 ± 22

12 ± 0

CD14

134 ± 36

19 ± 2

Chitinase 3-like 1

220 ± 20

9 ± 0

EGF

95 ± 20

12 ± 1

emmprin

124 ± 37

28 ± 1

ENA-78

112 ± 60

9 ± 1

Endoglin

166 ± 27

51 ± 0

IFN-γ

84 ± 9

66 ± 3

IL-8

192 ± 28

8 ± 0

Kallikrein 3

95 ± 40

79 ± 4

Lipocalin-2

162 ± 11

4 ± 0

MIF

149 ± 11

7 ± 0

MMP-9

150 ± 22

3 ± 0

Myeloperoxidase

153 ± 10

91 ± 0

Osteopontin

105 ± 22

69 ± 5

PDGF-AA

174 ± 29

13 ± 2

pentraxin 3

174 ± 9

165 ± 2

PF4

133 ± 29

4 ± 0

RANTES

149 ± 27

16 ± 0

RBP4

132 ± 55

115 ± 2

Resistin

113 ± 60

27 ± 0

PAI-1

255 ± 0

12 ± 0

Thrombospondin-1

119 ± 14

3 ± 0

uPAR

147 ± 60

9 ± 1

Vitamin D BP

138 ± 25

68 ± 5

CD31

130 ± 5

5 ± 0

  1. Cytokines selected for subsequent ELISA-assisted quantifications are highlighted in italics
  2. BAFF B cell activating factor, CD14 cluster of differentiation 14, EGF epidermal growth factor, ENA-78 epithelial-derived neutrophil-activating protein 78, IFN-γ interferon gamma, IL-8 interleukin-8, MIF macrophage migration inhibitory factor, MMP9 matrix metallopeptidase 9, PDGF-AA platelet-derived growth factor subunit A, PF4 platelet factor 4, RANTES regulated and normal T cell expressed and secreted, RBP retinol binding protein, PAI-1 plasminogen activator inhibitor-1, uPAR urokinase-type plasminogen activator receptor, vitamin D-BP vitamin D-binding protein, CD31 cluster of differentiation 31