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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Preconditioning of mesenchymal stromal cells with low-intensity ultrasound: influence on chondrogenesis and directed SOX9 signaling pathways

Fig. 1

Schematic representation of the possible SOX9-directed pathways under cLIUS stimulation. The diagram shows putative signaling pathways that may be activated upon cLIUS stimulation in MSCs leading to the gene expression of SOX9 and its target gene COL2A1. Select intracellular signaling molecules (ERK1/2 and PKA), upstream effectors (integrin and TRPV4), and the actin cytoskeleton were targeted by pharmacological inhibition to investigate the involvement of integrin-MAPK or calcium signaling through TRPV4 pathways leading to SOX9 upregulation under cLIUS in MSCs

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