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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Cellular therapy of corneal epithelial defect by adipose mesenchymal stem cell-derived epithelial progenitors

Fig. 6

Corneal tissue changes after transplantation of tissue-engineered cell/fibrin gel constructs to the alkali-injured corneal surface. a. Representative H&E images of corneas. b Homing of Molday-ION Evergreen™ labeled human MET-Epi cells in the cornea (predominantly in basal layers) at week 4 post-transplantation. Similar result was revealed by human-specific HuNu staining (arrows). c Immunofluorescence of corneal epithelial marker expression at 4 weeks post-transplantation. CK3, CK12, and CDH1 (E-cadherin) were upregulated in reconstructed epithelial layers after TE-MET-Epi transplantation, but not in TE-ADSC transplanted group. In contrast, CDH2 (N-cadherin) was suppressed in TE-MET-Epi transplanted corneas. Scale bars: 0.1 mm

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Stem Cell Research & Therapy

ISSN: 1757-6512