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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Influence of mesenchymal stem cell-derived extracellular vesicles in vitro and their role in ageing

Fig. 6

Study of mTOR family in MSCs. a The histograms represent the gene expression of mTOR, Rictor and AKT normalised by HPRT, a housekeeping gene, in old MSCs with or without young MSC-derived EVs at different times (2, 3 and 6 days). b The histograms represent the gene expression of mTOR, Rictor and AKT gene expression normalised by HPRT, a housekeeping gene, in young MSCs with or without old MSC-derived EVs at different times (2, 3 and 6 days). *P < 0.05 compared with the former group was considered statistically significant using Mann-Whitney U and Kruskal-Wallis tests. c Western blot analysis of phospho-mTOR, Rictor and phospho-AKT from old MSCs with or without young MSC-derived EVs at different times (2, 3 and 6 days). d Western blot analysis of phospho-mTOR, Rictor and phospho-AKT from young MSCs with or without old MSC-derived EVs at different times (2, 3 and 6 days). The molecular weight of each protein is shown on the left. One representative experiment is shown. The gels have been run under the same experimental conditions. Control, MSCs cultured with growth medium without EVs; oMSC, MSCs from the old group; yMSC, MSCs from the young group; oEV, MSC-derived EVs from the old group; yEV, MSC-derived EVs from the young group

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