Skip to main content
Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8+CD28− T cells

Fig. 4

Histopathological examination of ovarian tissues. Photomicrographs (× 100) show HE stained ovaries. a Control group. b POF group. c MSC group. d NC group. e HO-1 group. f shHO-1 group. g DMSO group. h Anisomycin group. i SP600125 group. The five types of ovarian follicles were marked as (1) primordial follicles, (2) primarily follicles, (3) secondary follicles, (4) antral follicles, and (5) atresia follicles. j–l Quantitation on follicle count from ovaries in mice of the nine groups. Data presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 vs DMSO, GC group, or NC group, separately. Bar scale = 200 μm. DMSO, dimethylsulfoxide; HE, hematoxylin and eosin; HO-1, heme oxygenase-1; NC, empty vector; POF, premature ovarian failure; UCMSCs, umbilical cord mesenchymal stem cells

Back to article page