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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8+CD28− T cells

Fig. 8

Effects of HO-1 gene expressed in the UCMSCs on ratios of CD8+CD28− T cells with the administration of anisomycin or SP600125. a Representative flow cytometric plots for CD8+CD28− T acquisition isolated from spleens in the nine groups, respectively. b The CD8+CD28− T cells population comparison among the control group, POF group, and MSC group. c The CD8+CD28− T cells population comparison among the DMSO group, SP600125 group, and anisomycin group. d The CD8+CD28− T cells population comparison among the NC group, HO-1 group, and shHO-1 group. *P < 0.05, **P < 0.01, ***P < 0.001 vs DMSO, GC group, or NC group, separately. DMSO, dimethylsulfoxide; HO-1, heme oxygenase-1; NC, empty vector; POF, premature ovarian failure; UCMSCs, umbilical cord mesenchymal stem cells

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Stem Cell Research & Therapy

ISSN: 1757-6512