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Table 1 Characteristics of the studies included in this meta-analysis

From: Efficacy of mesenchymal stem cells in animal models of lupus nephritis: a meta-analysis

Author, year n Type of animal MSC type Number of MSC Route of delivery Endpoints
Sun 2009 [10] 12 MRL/lpr mice BM-MSC 0.1 × 106 cells per 10 g body weight Intravenous ds-DNA, albumin, proteinuria, IgM, Foxp3, IL-6, IL-17
Gu 2010 [11] 8 MRL/lpr mice UC-MSC 1 × 106; multi-treatment (at the 18th, 19th, and 20th weeks of age) Intravenous Proteinuria, BUN, Scr, ds-DNA, MCP-1, Foxp3
Chang 2011 [12] 8 NZB/W F1 mice UC-MSC 1 × 106 Intravenous Proteinuria, Scr, ds-DNA, IFN-γ, TNF-α, IL-2, IL-6, IL-12, IL-4, IL-10, renal sclerosis score
Choi 2012 [13] 26 NZB/W F1 mice AD-MSC 1.4 × 107 Intravenous Proteinuria, BUN, Scr, ds-DNA
Ji 2012 [14] 10 MRL/lpr mice BM-MSC 0.2 × 106 cells per 10 g body Intravenous ds-DNA, ANA, proteinuria
Ma 2013 [15] 9 MRL/lpr mice BM-MSC 1 × 106 Intravenous Proteinuria, ds-DNA
Li 2013 [16] 7 129X1/svj mice BM-MSC 1 × 106 Intravenous Proteinuria, BUN, renal sclerosis score, MCP-1
Liu 2014 [17] 4 MRL/lpr mice BM-MSC 1 × 106 Intravenous Proteinuria, Scr
Che 2014 [18] 10 MRL/lpr mice BM-MSC 0.1 × 106 cells per 10 g body Intravenous ds-DNA, ANA, IL-10, TGF-β
Park 2015 [19] 6 Roquinsan/san mice AD-MSC 1 × 106 for 5 weeks Intravenous IgM, ds-DNA, Th1, Th17, Treg
Choi 2015 [20] 15 MRL/lpr mice AD-MSC 1 × 106 Intravenous Proteinuria, MCP-1, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-12, IL-15, IL-17
Jang 2016 [21] 8 NZB/W mice BM-MSC 1 × 106 for 5 weeks Intravenous ds-DNA, proteinuria
Choi 2016 [22] 15 NZB/W mice AD-MSC 5 × 105 for 27 times Intravenous BUN, ds-DNA
Yuan 2016 [23] 16 MRL/Lpr mice human early embryonic MSC (hMSC) 1 × 106 Intravenous ds-DNA, albumin, proteinuria, Scr, BUN, IL-17, IL-10, TGF-β
He 2016 [24] 6 B6.MRL/lpr mice AD-MSC 1 × 106 Intravenous ds-DNA, proteinuria, IL-17, IL-6, INF-γ, TGF-β, TNF-α
Choi 2016 [25] 20 C3.MRL-Faslpr/J mice AD-MSC 1 × 106 Intravenous ds-DNA, Scr, BUN, Treg, Th1
Zhang 2017 [26] 5 B6.MRL-Faslpr mice UC-MSC 1 × 106 Intravenous ds-DNA, Th17, renal sclerosis score
Lee 2017 [27] 5 MRL-Faslpr mice BM-MSC 4 × 106 Intravenous ds-DNA, proteinuria
Yang 2018 [28] 6 MRL/lpr mice BM-MSC 2 × 106 Intravenous Renal sclerosis score, proteinuria, ds-DNA
Tani 2017 [29] 5 NZB/W F1 mice BM-MSC 1 × 106 Intravenous Proteinuria, ds-DNA, renal sclerosis score
Mai 2018 [30] 4 MRL/lpr mice UC-MSC 1 × 106 Intravenous ds-DNA, proteinuria, IFN-γ, TGF-β, MCP-1, IgM, IL-2, IL-10
Ma 2018 [31] 8 MRL/lpr mice UC-MSC 1 × 106 Intravenous Scr, proteinuria, IgM, C3,
Zhang 2019 [32] 3 B6.MRL-Faslpr mice UC-MSC 1 × 106 Intravenous Renal sclerosis score, proteinuria, ds-DNA
Lee JH 2018 [33] 6 MRL-Faslpr mice BM-MSC 4 × 104 Intravenous ds-DNA, proteinuria
Huang 2018 [34] 12 MRL-Faslpr mice UC-MSC 1 × 106 Intravenous Renal sclerosis score, ds-DNA, proteinuria
Liu 2019 [35] 10 B6.MRL-Faslpr mice placenta-derived mesenchymal stem cells (pMSC) 1 × 106 Intravenous ds-DNA, proteinuria, TNF-α
Tang 2019 [36] 10 B6.MRL-Faslpr mice UC-MSC 2 × 105 per 10 g body Intravenous ds-DNA, proteinuria, ANA, IgG, IgM, renal sclerosis score, IL-6, IL-17, IL-10, MCP-1