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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Mesenchymal stem cells promote human melanocytes proliferation and resistance to apoptosis through PTEN pathway in vitiligo

Fig. 1

Vitiligo patients presented with high PTEN expression. a Clinical data of vitiligo patients (n = 3). b Principal component analysis of vitiligo skin samples. c Heatmap of vitiligo skin samples. The color scale indicates the log2 ratio of the normalized hybridization signal intensities of the regulated genes with a range of − 2.0 to + 2.0. d, e Regulated genes enriched in the KEGG database. Enrichment pathway analysis was performed in aggregated gene-base, and functional categories were set with a gene count log10 (P value< 0.05). The top upregulated pathway was selected and analyzed by log2FC. f to g GSEA graph of the upregulated PI3K/AKT/mTOR pathway and UV response in the vitiligo skin samples. P value < 0.01. h Transcriptomic data analysis of vitiligo lesion skin and non-lesion skin in GEO DataSets. PTEN expression in this study (series: GSE75819, n = 30). ** P value < 0.01

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