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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Mesenchymal stem cells alleviate liver injury induced by chronic-binge ethanol feeding in mice via release of TSG6 and suppression of STAT3 activation

Fig. 5

ao TSG-6 knockdown in MSCs weakened their immunomodulatory effects, and exogenous administration of rmTSG-6 replicated their effects in AH. Serum and hepatic IL-6 (ac), TNF-ɑ (df), Cox2 (g, h), IL-10 (ik), and TSG-6 (ln) mRNA and protein; Western blot results of hepatic tissue (o): lane 1, AH; lane 2, AH+MSCs; lane 3, AH+sc-MSCs; lane 4, AH+siTSG-6-MSCs; lane 5, AH+rmTSG-6. Five mice per group were used. *P < 0.05, **P < 0.01, ***P < 0.001

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