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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter

Fig. 4

CCA for integrated analysis of sorted and unsorted scRNA-seq datasets. a Five major conserved populations were identified after CCA alignment of the sorted and unsorted chondroprogenitor cells. b DEG analysis indicated that sorted cells exhibited significantly upregulated expression of several mesenchymal genes including TPM1, TAGLN, and TMSB10 (brown circle), which have been suggested to be essential in chondrogenesis. Proliferative markers including SOX4 (red circle) and TUBA1A (yellow circle) were increased, but IGFBP5 (blue circle) and several ribosomal genes were decreased in sorted cells

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Stem Cell Research & Therapy

ISSN: 1757-6512