Fig. 6

Sirius red staining to identify fibrosis. a Sirius red staining of cardiac sections 4 weeks after cell transplantation. Collagen fibers stain red, and cardiac muscle fibers stain yellow. b Quantification of fibrosis demonstrated that iPSC-CM therapy tended to reduce the amount of fibrosis compared with the CTL group, but there was no significant difference. CTL control, iPSC-CMs induced pluripotent stem cell-derived cardiomyocytes (CTL group: n = 5; iPS-CM group: n = 6). Unpaired two-tailed t-test, n.s. = not significant