Skip to main content
Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation

Fig. 3

MSC exosomes alleviate hypoxia-induced beta cell apoptosis by attenuating ER stress and p38 MAPK activation. a ER stress-related proteins (GRP78, GRP94, P-eIF2α, and CHOP), P38 MAPK signalling, and apoptosis-related proteins (cleaved caspase 3, PARP, and survivin) were detected by WB. β-Actin was used as a loading control. ER stress-related proteins and the phosphorylation of P38 MAPK were inhibited by MSC exosomes. b Densitometry assay with ImageJ. NOR, normoxia group; HYP, hypoxia group; HYP + EXO, hypoxia with 50 μg/mL exosomes group

Back to article page