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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Mesenchymal stem cells regulate the Th17/Treg cell balance partly through hepatocyte growth factor in vitro

Fig. 6

The regulatory effect of HGF secreted by MSCs on CD40+ and CD80+ monocyte activation in cocultures with CD4+ T cells and analysed with flow cytometry. The results showed that after being cocultured with MSCs, CD4+ T cells significantly inhibited monocyte expression of CD40 (p < 0.05, a) and CD80 (p < 0.05, b). However, the CD4+ T cell-mediated effect was inhibited by an anti-HGF antibody (p < 0.01) (n = 3; *p < 0.05 vs. the CD4+ group; ##p < 0.01 vs. the MSC+CD4+ group). MSCs, mesenchymal stem cells; rmHGF, recombinant mouse hepatocyte growth factor

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Stem Cell Research & Therapy

ISSN: 1757-6512