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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Mesenchymal stem cells regulate the Th17/Treg cell balance partly through hepatocyte growth factor in vitro

Fig. 7

The regulatory effect of HGF secreted by MSCs on MHC-II and TLR-2 expression in monocytes cocultured with CD4+ T cells and analysed with flow cytometry. The results showed that after being cocultured with MSCs, CD4+ T cells significantly inhibited monocyte expression of MHC-II (p < 0.01, a) and TLR2 (p < 0.05, b). However, the CD4+ T cell-mediated effect was inhibited by an anti-HGF antibody (p < 0.05 or p < 0.01) (n = 3; *p < 0.05 or **p < 0.01 vs. the CD4+ group; ##p < 0.01 vs. the MSC+CD4+ group). MSCs, mesenchymal stem cells; rmHGF, recombinant mouse hepatocyte growth factor

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Stem Cell Research & Therapy

ISSN: 1757-6512