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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Tumor necrosis factor α in aGVHD patients contributed to the impairment of recipient bone marrow MSC stemness and deficiency of their hematopoiesis-promotion capacity

Fig. 7

TNF-α blockage by a recombinant human TNF-α receptor (p75)–Fc fusion protein partially rescued MSC function. a The CFC and b cell sphere number significantly recovered in the presence of a recombinant human TNF-α receptor (p75)–Fc fusion protein. *p < 0.05, compared with aGVHD groups, n = 5. b The mRNA expression of Runx2, Osteorix, CEBP/α, and PPARγ were rescued by the addition of recombinant human TNF-α receptor (p75)–Fc fusion protein. *p < 0.05, **p < 0.01, compared with aGVHD groups, n = 5. d The CFC numbers in the bulk culture of long-term culture-initiating cells were partially rescued by recombinant human TNF-α receptor (p75)–Fc fusion protein. *p < 0.05, compared with aGVHD groups, n = 5

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