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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: MSC-derived exosomes attenuate cell death through suppressing AIF nucleus translocation and enhance cutaneous wound healing

Fig. 6

HucMSC-Ex promoted HaCaT cell migration of after H2O2 induction. HaCaT cells were treated with H2O2 then cultured in DMEM/F12 (H2O2 group), hucMSC-CM, hucMSC-dp-Ex, or hucMSC-Ex for 24 h. Control group: normal HaCaT cells. a, c Transwell cell migration assay showed that the hucMSC-CM and hucMSC-Ex treatments promoted HaCaT cell migration from the upper to lower chambers (n = 3; **P < 0.01). b, d HaCaT cells were treated with various culture media and subjected to a wound-healing assay for 12 h. Percentage closure of wounded areas was measured. The recovery of wound areas was higher in the hucMSC-Ex group than the PBS group (n = 3; **P < 0.01). Scale bar = 200 μm. Compared to control: *P < 0.05 and **P < 0.01; compared to H2O2:#P < 0.05 and ##P < 0.01. Data are representative of three independent experiments (means ± SD)

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