Table 3 Over-represented biological processes of the BM-MSC secretome under TNFα compared with control C1
Biological process | TNFα (P value) | Control C1 (P value) | ID (term GO) |
|---|---|---|---|
Positive regulation of GTPase activity | 1.76 × 10−20 | 2.65 × 10−01 | GO:0043547 |
Cellular response to tumor necrosis factor | 2.75 × 10−22 | 3.52 × 10−01 | GO:0071356 |
Granulocyte chemotaxis | 1.49 × 10−27 | 1.04 × 10−09 | GO:0071621 |
Positive regulation of ERK1 and ERK2 cascade | 3.34 × 10−19 | 4.51 × 10− 01 | GO:0070374 |
Cytokine-mediated signaling pathway | 6.74 × 10−29 | 1.32 × 10−07 | GO:0019221 |
Inflammatory response | 1.88 × 10−24 | 1.28 × 10−03 | GO:0006954 |
Antimicrobial humoral immune response mediated by antimicrobial peptide | 6.43 × 10−03 | – | GO:0061844 |
Cellular response to lipopolysaccharide | 1.18 × 10−02 | 3.24 × 10−04 | GO:0071222 |
MAPK cascade | 3.42 × 10−10 | 3.45 × 10−02 | GO:0000165 |
Innate immune response | 7.55 × 10−09 | – | GO:0045087 |