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Table 4 Upregulated proteins secreted by BM-MSC under TNFα stimulation compared with control C1

From: Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells

Protein

Biological processes

Abundance ratio (sample/Control C1)

P value

C-X-C motif chemokine 3

1, 2, 3, 4, 5

11.38

1 × 10−1

C-type lectin domain family 4 member E

3,4, 5, 6

8.464

1 × 10−17

Platelet factor 4

1, 3, 4, 7

5.818

5.54 × 10−10

C-X-C motif chemokine 10

1, 3, 4, 5

5.198

2.44 × 10−12

Pentraxin-related protein PTX3

3, 4, 5

4.613

5.66 × 10−11

Stromelysin-1

4, 5, 8

3.936

4.98 × 10−09

Isoform 2 of sequestosome-1

4, 5, 6, 7, 8, 9, 10

3.842

9.45 × 10−09

Neutrophil gelatinase-associated lipocalin

3, 4, 5, 7, 9, 10, 11

3.267

0.0002

CD82 antigen

4, 5

2.869

3.98 × 10−05

Tumor necrosis factor receptor superfamily member 1B

3, 4, 5, 12, 13

2.762

0.0006

Copper transport protein ATOX1

2, 5, 11

2.572

7.45 × 10−05

Prostaglandin G/H synthase 2

3, 4, 5, 6, 8

2.421

0.005

Intercellular adhesion molecule 1

1, 2, 3, 4, 5, 7, 9

2.107

0.002

GRIP1-associated protein 1

4, 8, 11

2.023

0.02

MAGUK p55 subfamily member 6

8

2.013

0.03

  1. Mass spectrometry analysis of secretome. The P value is calculated in a background-based ANOVA. This method uses the background population of ratios for all peptides and proteins to determine whether any given single peptide or protein is significantly changing relative to that background. Biological processes: 1, cellular component movement; 2, cellular homeostasis; 3, defense response; 4, regulation of biological process; 5, response to stimulus; 6, cell differentiation; 7, cell organization and biogenesis; 8, metabolic process; 9, cell communication; 10, cell death; 11, transport; 12, cell proliferation; 13, development. More data of these proteins is shown in Additional file 5
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Stem Cell Research & Therapy

ISSN: 1757-6512