Autologous bone marrow stem cell transplantation via the hepatic artery for the treatment of hepatitis B virus-related cirrhosis: a PRISMA-compliant meta-analysis based on the Chinese population

Table 3 Subgroup analyses of TBIL, ALB, ALT, and PT between the experimental and control group at the 4th week after therapy

Parameter	Factors at study level	Exp group	Con group	Analysis method	Heterogeneity		Mean difference (MD)	95% CI	P value
Parameter	Factors at study level	No. patients (n)	No. patients (n)	Analysis method	I² (%)	P value	Mean difference (MD)	95% CI	P value
TBIL	Cell number
	> 1 × 10¹⁰	52	50	Fixed	49	0.16	− 9.04	− 14.15 to − 3.92	0.0005
	< 1 × 10¹⁰	59	97	Fixed	0	0.41	− 3.03	− 17.60 to 11.54	0.68
	Study sample size
	> 50	144	180	Fixed	0	0.87	− 12.09	− 12.95 to − 11.12	< 0.00001
	≤ 50	57	58	Fixed	0	0.79	− 1.88	− 11.27 to 7.51	0.69
ALB	Cell number
	> 1 × 10¹⁰	52	50	Fixed	0	0.41	2.64	1.33 to 3.95	< 0.0001
	< 1 × 10¹⁰	119	160	Fixed	0	0.65	1.90	1.13 to 2.66	< 0.00001
	Study sample size
	> 50	171	209	Fixed	0	0.55	2.09	1.44 to 2.75	< 0.00001
	≤ 50	57	58	Fixed	0	0.47	0.70	− 1.34 to 2.74	0.50
ALT	Cell number
	> 1 × 10¹⁰	52	50	Random	69	0.07	− 10.67	− 28.02 to 6.67	0.23
	< 1 × 10¹⁰	99	140	Random	0	0.46	− 5.46	− 13.92 to 3.00	0.21
	Study sample size
	> 50	171	209	Random	79	0.0007	− 8.08	− 17.02 to 0.87	0.08
	≤ 50	37	38	Random	60	0.11	− 10.45	− 34.83 to 13.93	0.40
PT	Cell number
	> 1 × 10¹⁰	52	50	Random	90	0.002	− 2.84	− 6.07 to 0.39	0.08
	< 1 × 10¹⁰	39	77	Random			− 1.86	− 4.10 to 0.38	0.10
	Study sample size
	> 50	37	38	Random	0	0.50	− 1.45	− 2.94 to 0.05	0.06
	≤ 50	111	146	Random	89	< 0.0001	− 2.40	− 4.98 to 0.19	0.07

Abbreviations: Con group control group (RT alone group), Exp group experimental group (RT plus ABMSC therapy), RT routing therapy, TBIL total bilirubin, ALB albumin, ALT alanine aminotransferase, PT prothrombin time, RT routing therapy, ABMSC autologous bone marrow stem cell

ISSN: 1757-6512