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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Treatment of vocal fold scarring with autologous bone marrow-derived human mesenchymal stromal cells—first phase I/II human clinical study

Fig. 2

Vocal fold analysis of high-speed laryngoscopy. a (Top) Edge tracking of glottal area during vibration. Dots at midpoint of left and right vocal folds. Arrow marks length of membranous vocal fold part use for normalization of vibration and glottal area. b (Mid) Preoperative recording. c (Bottom) Postoperative recording for patient 12 with corresponding kymograms from the horizontal yellow line plane (left). Right vocal fold vibrations are shown above and left local fold below. Red vertical line at preoperative kymogram corresponds to maximum glottal closure (left image). High-Speed Studio software automatically sets glottal midline (red horizontal) and analyzes the brighter pixels at the most closed phase during each vibratory cycle in relation to the darker pixels during the open phase. Open/closed coefficient is calculated from this relation. Preoperative O/C coefficients in the figure are 73% preoperatively and 52% postoperatively indicating improved glottal closure. Preoperative, there is a time phase delay of maximum closure for the right vocal fold in comparison with the left vocal fold which is normalized after treatment of the right vocal fold

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