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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Mesenchymal stem cells ameliorate myocardial fibrosis in diabetic cardiomyopathy via the secretion of prostaglandin E2

Fig. 2

MSCs ameliorated abnormal cardiac structure and function in DCM rats. After MSC treatment, echocardiography (a–c) was used to evaluate cardiac structure, including left ventricular end-diastolic internal diameters (LVIDD; d) and LV end-systolic internal diameters (LVIDS; e), cardiac systolic function containing left ventricular ejection fraction (LVEF; f) and fractional shortening (FS; g) and cardiac diastolic function, including the early to late diastolic mitral annular velocity (E’/A’; h) ratio for different groups. n = 3–5, *P < 0.05, **P < 0.005. Rat cardiac photographs were taken to present the whole heart morphology of different groups after rats were euthanized (i). At the end of the experiment, body weight and heart weight of rats were measured, and the ratio of heart weight to body weight (HW/BW) was calculated (j). n = 6, **P < 0.005. ac The size of ventricular chamber and the thickness of the anterior and posterior ventricular wall at the end-diastole and end-systole, respectively. Arrow in i indicated the collapsed ventricular wall

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