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Table 1 Baseline data

From: Autologous adipose-derived stem cells for the treatment of Crohn’s fistula-in-ano: an open-label, controlled trial

Contents

Observation group (n = 11)

Control group (n = 11)

Sex

Male

11 (100.0%)

10 (90.9%)

Female

0 (0.0%)

1 (9.1%)

Age (year)

24.4 ± 5.0

24.9 ± 5.4

BMI (kg/m2)

21.8 ± 3.0

19.9 ± 2.6

Volume of fat (mL)

48.4 ± 23.1

Number of cells (×106cells)

142.3 ± 45.7

Simplified CDAI

4.3 ± 0.5

4.4 ± 0.7

PDAI*

8.5 ± 1.4

9.5 ± 1.7

IBDQ

143.5 ± 19.8

137.9 ± 29.7

VAS§

0.8 ± 1.0

1.1 ± 1.0

Wexner

1.2 ± 1.3

1.5 ± 0.7

Location of Crohn’s disease

Ileum (L1)

1 (9.1%)

1 (9.1%)

Colon (L2)

4 (36.4%)

3 (27.3%)

Ileocolon (L3)

6 (54.6%)

7 (63.6%)

Upper gastrointestinal (L4)

0 (0.0%)

0 (0.0%)

Classification of fistula-in-ano (Parks)

Transsphincteric

4 (36.4%)

7 (63.6%)

Suprasphincteric

1 (9.1%)

0 (0.0%)

Intersphincteric

4 (36.4%)

3 (27.3%)

Extrasphincteric

2 (18.2%)

1 (9.1%)

Number of internal openings

 1

9 (81.8%)

10 (90.9%)

 2

2 (18.2%)

1 (9.1%)

Number of external openings

 1

5 (45.4%)

5 (45.4%)

 2

3 (27.3%)

4 (36.4%)

 3

2 (18.2%)

2 (18.2%)

 4

1 (9.1%)

0 (0.0%)

Drug use at baseline

ASA

11/11 (100.0%)

11/11 (100.0%)

Probiotics

11/11 (100.0%)

11/11 (100.0%)

Immunomodulators

1/11 (9.1%)

3/11 (27.3%)

Antibiotics

1/11 (9.1%)

1/11 (9.1%)

Anti-TNF

0/11 (0.0%)

0/11 (0.0%)

Glucocorticoids

0/11 (0.0%)

0/11 (0.0%)

  1. Data are mean (SD) or number (%). Percentages might not always add up to exactly 100% as a result of rounding. BMI = body mass index. ASA = aminosalicylic acid. TNF = tumor necrosis factor. †Scores Less than 4 is divided into remission period, 5–8 is divided into moderate active period, and more than 9 is divided into severe active period. *Scores range from 0 to 20; higher scores suggest more severe disease. ‡Scores range from 32 to 224; higher scores suggest better quality of life. §Scores range from 0 to 10; higher scores suggest more severe degree of pain. ¶Scores range from 0 to 20; higher scores suggest more severe degree of anal incontinence