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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Exosomes derived from human umbilical cord mesenchymal stem cells inhibit vein graft intimal hyperplasia and accelerate reendothelialization by enhancing endothelial function

Fig. 3

hucMSC-exosomes accelerated reendothelialization in arterialized vein grafts. a Immunohistochemical staining of vascular endothelial cell marker CD31 (red) in vein grafts from the PBS group (left panel) and exosome group (right panel) to assess endothelial recovery. Scale bar is 200 μm. b Quantitative analysis of reendothelialization in vein grafts at 14 days after vein grafting. Reendothelialization was expressed as a percentage of the CD31-positive stained luminal surface to the total luminal surface. c Representative western blots (top panel) and quantitative analysis (lower panel) of CD31protein expression in vein grafts from the PBS and exosome groups. The mRNA levels of eNOS (d) and iNOS (e) in vein grafts from the normal vein, PBS, and exosome groups were detected by RT-PCR. f Representative western blots of eNOS and iNOS protein expression in vein grafts from the normal vein, PBS, and exosome groups. Effects of hucMSC-exosome administration on eNOS (g) and iNOS (h) protein expression were quantified. The results are presented as the mean ± SD, n = 6 for each group. An asterisk represents statistically significant difference compared with the PBS group (P < 0.05). Number sign represents statistically significant difference compared with the normal vein group (P < 0.05)

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