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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: High cholesterol induces apoptosis and autophagy through the ROS-activated AKT/FOXO1 pathway in tendon-derived stem cells

Fig. 5

Cholesterol stimulates cellular ROS generation in TDSCs. a, b TDSCs were treated with the indicated concentrations of cholesterol for 24 h, followed by detection of ROS levels by flow cytometry. c, d TDSCs were treated with cholesterol (10 mg/dL) for different periods of time, followed by detection of ROS levels by flow cytometry. e, f TDSCs were pretreated with NAC (5 mM, 1 h) before incubation with 10 mg/dL cholesterol and NAC for 24 h, followed by detection of ROS levels by flow cytometry. All quantitative data are expressed as the means ± SEM of the results from three independent experiments. *p < 0.05 versus control

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