From: Mending a broken heart: current strategies and limitations of cell-based therapy
 | Characteristics | PSC-CM | Adult CM | References |
---|---|---|---|---|
Morphology | Cell shape | Circular | Rod-shaped | |
Nucleation | Single nucleated | 25–30% binucleated | ||
Mitochondrial content | Slender and long, lesser than in adult CM | Elongated shape, 35% of total cell volume | ||
Surface area | 1000-1300 μm2 | 10,000-14,000 μm2 | ||
Metabolism | Substrate preference | Glucose | Fatty acid | |
Sarcomere | Myofibrillar isoform switch (myosin heavy chain) | β = α | β > > α | |
Myofibril | Low density | High density | ||
Alignment | Random | Anisotropic | ||
Electrophysiological properties | Upstroke velocity | Slower | Faster | |
Contraction | Asynchronous | Synchronous |