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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Characterization of immortalized human islet stromal cells reveals a MSC-like profile with pancreatic features

Fig. 5

hISCs inhibit PBMCs proliferation. a Phase-contrast microscopic view of activated PBMCs after 96 h of co-culture with hISCs (top) or BM-MSCs (bottom). PHA activation induces the proliferation of PBMCs, which form suspended cell clusters (on the left). The number of PBMCs clusters decreases inversely with the ratio MSC to PBMC. The proliferation of PBMCs cultured alone (CTRL) or with hISCs or BM-MSCs at four ratios (1:5, 1:10, 1:20, 1:40; MSC to PBMC) was quantified. PBMCs proliferation was reduced by hISCs (b) and BM-MSCs (c) in co-culture. The inhibitory effect of both cell types was higher with increasing ratio. Results are representative of four independent experiments. *p < 0.05; **p < 0.001; ***p < 0.0001 when compared to the control. Scale bar = 500 μm

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