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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: HIF1α overexpression enhances diabetic wound closure in high glucose and low oxygen conditions by promoting adipose-derived stem cell paracrine function and survival

Fig. 3

VEGFR2 mediates HIF1α-overexpressing ADSC-induced protection of MAECs in high glucose/low oxygen. a The proliferation of MAECs treated with the VEGFR2 inhibitor ZD6474 and cocultured with control or HIF1α-overexpressing ADSCs under high glucose was analyzed by MTT assay. b Apoptotic MAECs after coculture as in a. c Representative images of MAEC wound healing assays at 0, 24, and 48 h (scale bars, 200 μm). d MAEC wound healing after 0, 24, and 48 h. All experiments were performed under hypoxia. Cells cultured in normal glucose levels and treated with PBS were used as controls. **p < 0.01; *p < 0.05; High, high glucose; HIF1α, HIF1α overexpression; ZD6474, cells treated with ZD6474

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Stem Cell Research & Therapy

ISSN: 1757-6512