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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Comprehensive analysis of skeletal muscle- and bone-derived mesenchymal stem/stromal cells in patients with osteoarthritis and femoral neck fracture

Fig. 7

In vitro immunophenotype and gene profiling of markers of MSC subpopulations. Flow cytometry was used to determine the rate of positive (a) and negative (b) markers, according to the International Society of Cellular Therapy [25]. Gene expression profiling for MSC markers in the muscle (c) and bone-derived MSCs (d) revealed that the LEPR gene was significantly downregulated in OA patients in bone-derived MSCs, compared to OP patients and controls (means 0.0085 vs. 0.334 and 1.076; p = 0.005, 0.040, respectively) (d). There were no differences for the muscle-derived MSCs between the tested groups (c)

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Stem Cell Research & Therapy

ISSN: 1757-6512