Skip to main content
Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway

Fig. 7

VO-OHpic alleviates MPS-induced osteonecrosis of the femoral head in rats. a Representative micro-CT images of the femoral heads (horizontal plane, coronal plane, and 3D reconstruction images). b The microstructural parameters of subchondral trabecular bone including bone volume (BV), bone volume/total volume (BV/TV), and bone surface/trabecular bone volume (BS/BV) were quantitatively evaluated in rats treated with MPS or treated with MPS and VO-OHpic. ∗P < 0.05 versus control, #P < 0.05 versus MPS group. Error bar represents SD. c HE staining of the rat femoral head was shown in the coronal plane (scale bar = 1 mm). d Local magnification showed that more empty bone lacunae were present in the MPS group compared to the control, while in the MP + VO-OHpic group, there is less empty bone lacunae compared to the MPS group (scale bar = 100 μm). Each group consisted of 10 rats/20 femoral heads (N = 20)

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512