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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Isolation and characterisation of nasoseptal cartilage stem/progenitor cells and their role in the chondrogenic niche

Fig. 4

Chondrogenic potential of CDC, DNC and CSPC populations. a Relative gene expression of chondrogenic-, proliferative- and progenitor-related genes in CDCs, DNCs and CSPCs. Expression levels were normalised to the level of RPLP0, and relative expression was calculated against CDCs. CCND2, cell cycle cyclin D2; BMP2, bone morphogenetic protein 2; COL1A1, type 1 collagen; COL2A1, type 2 collagen; ACAN, aggrecan; CXCL12, C-X-C motif chemokine 12; NCAM1, neural cell adhesion molecule 1; SOX9, sex-determining region Y box 9. Results as mean ± SEM from 6 independent experiments (n = 6) in technical triplicates, *p < 0.05, **p < 0.01 and ***p < 0.001. b–j Histology staining of b–d CDCs, e–g DNCs and h–j CSPCs at P2 using b, e and h Alcian blue; c, f and i Safranin-O; and d, g and j toluidine blue. Images are representative from 3 independent experiments (n = 3). Scale bars, 100 μm

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