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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Vitamin C improves the therapeutic potential of human amniotic epithelial cells in premature ovarian insufficiency disease

Fig. 4

VC-hAEC transplantation showed a more beneficial rescue effect than hAECs on ovarian function in the POI mouse model. a, b HE-stained ovarian sections of a CTX-induced POI mouse model showing follicle phenotypes. The numbers of antral and overall follicles were calculated and are presented below. The corpus luteum (CF), primordial follicles (PF), primary follicles (1F), secondary follicles (2F), and antral follicle (AF) are indicated by red arrows. Scale bar = 100 μm. ce Blood levels of AMH, E2, and FSH in a CTX-induced POI mouse model after transplantation of hAECs and VC-hAECs. One-way ANOVA was performed followed by Scheffe’s t test, *p < 0.05, versus hAECs group. NG = normal group with wild-type mice, POI = CTX-induced POI model mice, hAECs = CTX-induced POI model mice transplanted with hAECs, VC-hAECs = CTX-induced POI model mice transplanted with VC-treated hAECs

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