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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Vitamin C improves the therapeutic potential of human amniotic epithelial cells in premature ovarian insufficiency disease

Fig. 6

VC-hAEC transplantation showed a more powerful effect than hAECs on preserving ovarian marker expression in CTX-damaged ovaries. a, b FACS results showing the percent FSHR+AMH+ and FOXL2+CYP19A1+ ovarian cells in the CTX-induced POI mouse model. One-way ANOVA was performed followed by Scheffe’s t test, *p < 0.05, versus hAEC group. c Fluorescence images of mouse ovarian sections at 3, 7, and 14 days after transplantation of hAECs and VC-hAECs. CTX-damaged ovarian cells were stained with MVH (red). Yellow arrows indicate transplanted hAECs or VC-hAECs. Transplanted hAECs and VC-hAECs were labeled by DiO. Scale bar = 20 μm. NG = normal group with ovarian cells from wild-type mice, POI = ovarian cells from CTX-induced POI model mice, hAECs = ovarian cells from CTX-induced POI model mice transplanted with hAECs, VC-hAECs = ovarian cells from CTX-induced POI model mice transplanted with VC-treated hAECs

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