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Table 2 EV-miRNAs in the first quartile of expression that are involved in macrophage M1 or M2 phenotype

From: Inflammatory priming enhances mesenchymal stromal cell secretome potential as a clinical product for regenerative medicine approaches through secreted factors and EV-miRNAs: the example of joint disease

 

% weight EVs/iEVs

Down IFNγ

Up IFNγ

Only EVs

Only iEVs

M1 promoting

M1 suppressing

M2 promoting

M2 suppressing

M1 phenotype

 miR-29b-3p

0.07/0.27

 

X

  

X

   

 miR-145-5p

1.84/0.79

X

   

X

   

 miR-27a-3p

0.90/0.33

X

   

X

  

X

 miR-27b-3p

0.32/0.18

X

   

X

  

X

 miR-130a-3p

0.57/0.78

    

X

  

X

 miR-26a-5p

0.64/1.06

       

X

 miR-26b-5p

0.15/0.20

       

X

M2 phenotype

 miR-24-3p

19.63/18.47

     

X

X

 

 miR-146b-5p

0.04/0.51

 

X

   

X

X

 

 miR-181a-5p

0.11/0.18

     

X

X

 

 miR-34a-5p

0.70/0.93

      

X

 

 miR-222-3p

5.74/7.61

      

X

 
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Stem Cell Research & Therapy

ISSN: 1757-6512