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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: MiR-153 reduces stem cell-like phenotype and tumor growth of lung adenocarcinoma by targeting Jagged1

Fig. 3

miR-153 suppressed Jagged1/Notch pathway and reduced lung carcinoma cell stemness. a Jagged1 mRNA expression in indicated cells was determined by qPCR. b Protein expression of Jagged1, NCID, and Notch target gene Hes1 were determined by Western blot. c Tumor sphere formation capacity of SPC-A-1 cells was analyzed after Jagged1 overexpression. d Stem cell marker CD133 expression was determined by immunofluorescence. Scale bar, 50 μm. Data shown are mean ± s.d. of three independent experiments. *P < 0.05 by two-tailed Student’s t test

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