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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db/db mice

Fig. 3

AD-MSC-conditioned medium administration increases neurite regeneration in DRG neuronal cultures derived from diabetic mice. a Representative binary images of DRG neurons cultured in vitro derived of non-diabetic and diabetic mice treated in vivo with vehicle, conditioned medium derived from non-preconditioned AD-MSCs, or conditioned medium derived from DFX-preconditioned AD-MSCs. b Sholl analysis of neurons. c Quantification of maximum radius and d number of intersections per neuron derived from Sholl analysis (n = 4 different cultures, 120 total neurons analyzed per condition, one-way ANOVA with Tukey post-test, *p < 0.05)

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