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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db/db mice

Fig. 5

AD-MSC-conditioned medium administration improves irrigation of peripheral nerves in diabetic mice. a Representative confocal images of longitudinal sections of sciatic nerves obtained from 26-week-old non-diabetic and diabetic mice treated with vehicle, conditioned medium derived from non-preconditioned AD-MSCs, or conditioned medium derived from DFX-preconditioned AD-MSCs. Blood vessels were stained with BS-1Lectin. b Quantification of vascular area in sciatic nerves. c Representative bright-field images of gastrocnemius muscle sections stained with hematoxylin and eosin for blood vessel detection. Arrows indicate blood vessels. d Quantification of blood vessel density in gastrocnemius muscle. Data are presented as number of blood vessels per muscle fiber. Quantitative data are presented as mean ± S.E.M. (n = 6, one-way ANOVA with Tukey post-test, *p < 0.05)

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Stem Cell Research & Therapy

ISSN: 1757-6512