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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Regenerative and protective effects of dMSC-sEVs on high-glucose-induced senescent fibroblasts by suppressing RAGE pathway and activating Smad pathway

Fig. 8

dMSC-sEVs suppressed RAGE pathway and activated Smad pathway. a, b The expression level of RAGE, p21 RAS, and pSmad2/3 in HG aged HDFs with or without dMSC-sEVs. c The expression level of pSmad2/3 in HG aged HDFs treated with dMSC-sEVs or SB431542. The results were normalized to GAPDH expression (n = 5). d, e SA-β-gal expression in HG aged HDFs treated with dMSC-sEVs or SB431542. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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