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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Bone marrow mesenchymal stem cells improve bone erosion in collagen-induced arthritis by inhibiting osteoclasia-related factors and differentiating into chondrocytes

Fig. 2

BMSCs alleviated inflammatory responses and prevented joint damage in CIA rats. a Swelling of the ankle joints in CIA rats was obvious and relieved after BMSCs or MTX intervention. b Compared with the normal group, the arthritis index (AI) value in the CIA model group increased; however, it showed a downward trend from the second week after BMSC and MTX intervention. *P < 0.05; **P < 0.01; ***P < 0.001. c X-ray image showed that CIA rats had a narrow ankle and toe joint space, bristle edge, and joint destruction, and joint erosion was reduced after BMSC or MTX intervention. d Significant osteoporosis and bone destruction were observed in the ankle joint of CIA rats but improved in the BMSC and MTX intervention groups on micro-computed tomographic imaging. e Compared to the CIA group, BMSCs can increase the level of BV/TV, Tb. N, and Tb. Th and reduce the value of Tb. Sp. f Joint pathology findings suggested that synovial hyperplasia, inflammatory cell infiltration, and cartilage destruction were observed in the CIA rat group but were attenuated in the BMSC and MTX intervention group (HE, × 20)

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Stem Cell Research & Therapy

ISSN: 1757-6512