Table 1 MSCs treatment for influenza virus induced lung injury in vitro
Cell sources | Passage number | Influenza virus | Cell models | Biological effect |
|---|---|---|---|---|
Human BM MSCs | Not reported | H5N1 | Alveolar epithelial cells | Coculture with MSCs reduces AFC, APP, proinflammatory cytokine responses and prevents down-regulated sodium and chloride transporters [32]. |
Human UC MSCs | P4-5 | H5N1 | Alveolar epithelial cells | UC-MSCs correct impaired AFC, APP and restore ion transporters. They also regulate inflammatory responses [34]. |
Human UC MSCs derived CM | P4-5 | H5N1 | Alveolar epithelial cells | CM from UC-MSCs restores impaired AFC and APP [34]. |
Human UC MSCs derived EVs | P4-5 | H5N1 | Alveolar epithelial cells | UC-MSC exosomes restore impaired AFC and APP [34]. |
Swine BM MSCs derived EVs | P3-5 | H1N1/H7N2/H9N5 | Lung epithelial cells | MSC-EVs inhibited influenza virus replication and virus-induced apoptosis in lung epithelial cells [35]. |
Human BM MSCs | P1-5 | Influenza virus | CD8+ T cells | MSCs inhibited proliferation of virus-specificCD8+ T cells and the release of IFN-γ by specific CD8+ T cells [36]. |