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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Tetramethylpyrazine enhanced the therapeutic effects of human umbilical cord mesenchymal stem cells in experimental autoimmune encephalomyelitis mice through Nrf2/HO-1 signaling pathway

Fig. 8

TMP-stimulated hUCMSCs decrease demyelination in EAE mice. a LFB staining was carried out to detect the extent of demyelination. The black arrowheads pointed to the demyelination area. b Statistical analysis of the demyelination in each group. c Detection of the extent of demyelination stained by LFB in a high magnification. The delineation of box, circle, and triangle in c is corresponding to those in a. d MBP staining in each group. d Statistical analysis of the fluorescence intensity of MBP in each mouse of each group. Columns, mean; scale bar = 50 μm, SEM. **P < 0.01, ***P < 0.001 compared to PBS treatment. #P < 0.05 compared to hUCMSC treatment alone. The results are representative of three independent experiments

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Stem Cell Research & Therapy

ISSN: 1757-6512