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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Extracellular vesicles derived from human ES-MSCs protect retinal ganglion cells and preserve retinal function in a rodent model of optic nerve injury

Fig. 5

Retinal nerve fiber layer thickness (RNFL) 60 days post-treatment. a Immunostaining against Tuj1 as a neural marker. The nuclei were counterstained with DAPI. b The diameter of the Tuj1+ area revealed by immunostaining in (a). The vehicle group had a decreased retinal nerve fiber layer (RNFL) compared with the extracellular vesicle (EV) group. Data are presented as Violin plot for four optic nerves per group. The data were analyzed by the un-paired t test. ***P < 0.001. c Representative image of mice eye from dorsal view, enucleated 15 and 30 min post-injection of Calcein-labeled EVs via tail vein

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