Table 1 Diverse roles of Msi1 in different cell
From: Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells
Cell type | Function | Mechanisms | References |
|---|---|---|---|
Mammary stem/progenitor cells | Cell proliferation | Activation of Notch and Wnt pathways | Imai, 2001; Wang, 2008 |
Intestinal epithelium cells | Controls of cell cycle and cell proliferation | Stabilizing Ccnd1/CCND1, Cdk6/CDK6 and sox4/SOX4 | Cambuli, 2013 & 2015 |
Oligodendrocyte progenitor cells (OP) | Transition cell fate (Prevention of differentiation) | de-repression of p21WAF1/CIP1 | Dobson, 2008; MacNicol, 2015 |
Germ cell developments | Spermatogenesis and Oocyte maturation | Prevention of MSI2 and Erh RNA-binding activity, Activating translation of ePABP and PABPC1 | Sutherland, 2014 & 2015; Cragle, 2019 |