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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA

Fig. 8

The biological behaviors of survived CPCs after senolytics and IHP combined treatment in vivo. a Representative immunofluorescence staining for CD105 positive (green), P53 positive (red) cells of the medial femoral condyles of the rats. b Representative immunofluorescence staining for CD105-positive (green), Ki67-positive (red) cells. c Representative immunofluorescence staining for CD105-positive (red), PCNA-positive (green) cells. d–f Quantitative analyses of CD105+/P53+ cells (d), CD105+/Ki67+ cells (e), and CD105+/PCNA+ cells (f) between different treatment groups (three random fields were selected, n = 6 sections/rat, N = 5 rats per group). g Representative immunofluorescence staining for CD105-positive (green), SOX9-positive (red) cells. h Quantitative analyses of CD105+/SOX9+ cells between different treatment groups (three random fields were selected, n = 6 sections/rat, N = 5 rats per group). a–c, g Scale bar 50 μm. d–f, h Values are shown as mean ± SD. NS, no significance; *P < 0.05, **P < 0.01, one-way ANOVA with Tukey’s multiple comparisons test

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