Fig. 6From: SHP2 mutations induce precocious gliogenesis of Noonan syndrome-derived iPSCs during neural development in vitroExtracellular spontaneous firing in NS-cerebral organoids. a Raster plot for extracellular spontaneous firing of cerebral organoids cultured for 62 day. b, c Number of extracellular spikes and spike frequency of cerebral organoids. Reduced number of extracellular spikes and spike frequency were improved by SHP2 inhibition in NS-cerebral organoids at day 62 of differentiation (n = 3). p values were determined using an unpaired Student’s t test. *p < 0.05, **p < 0.01, ***p < 0.001. d A putative model for neurodevelopmental abnormalities of NS-iPSCs. Abbreviation: WT, wild-type; NS, Noonan syndrome; PHPS1, phenylhydrazonopyrazolone sulfonate 1Back to article page