Fig. 3
Evaluation of functional recovery in a murine hindlimb ischemia model. a The ratio of blood perfusion was investigated by laser Doppler perfusion imaging analysis in the ischemic limbs of normal mice injected with PBS, uninduced MSCs, and induced MSCs at 0, 7, 14, and 28 days post-operation. Representative pictures were shown. The former one is the normal control side, and the latter one is the operation side; data are expressed as the rate of LDPI index of the ischemic limb to the non-ischemic hind limb. b The ratio of blood perfusion was measured. Results are expressed as mean ± SEM; asterisk (*) indicates significant difference of the induced MSCs groups versus uninduced MSCs group, p < 0.05. c The distribution of the different outcomes on postoperative day 28. d Representative images illustrating the various outcomes: limb loss and limb salvage