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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes

Fig. 7

ChIP analyses of TRF3 at the promoter regions of ME markers at undifferentiated status (ME D0) and ME D1 induction of hESCs. a Gene concept network displaying the representative gene names associated with differentiation or development at ME D1. b Genome browser screenshots of ChIP-seq for T, EOMES, MIXL1, and GSC at the ME D0 and day 1. c ChIP-qPCR analyses of TRF3 at the transcription start sites (TSS) of ME markers (EOMES, T, MIXL1, and GSC) in TRF3−/−-1+vector and TRF3−/−-1+TRF3 hESCs. Data are presented as mean ± SEM. n = 3 each. *p < 0.05, **p < 0.01, ***p < 0.001 compared with the corresponding vector overexpressing values at differentiation day 1

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Stem Cell Research & Therapy

ISSN: 1757-6512