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Table 1 Expression changes of target antigens of selected MAbs in hMSCs stimulated with osteogenic inducers and in Runx2 knockdown U2OS cells

From: Expression dynamics of integrin α2, α3, and αV upon osteogenic differentiation of human mesenchymal stem cells

Clone Isotype hMSCs Runx2 knockdown U2OS
TGF-β1 + BMP-2 ODM
CD146
ER3-A7 IgG1, κ ↑↑ ↑↑
ER3-F3 IgG2a, κ ↑↑
ER7-A7 IgG2a, κ ↑↑
ER7-A8 IgG1, κ ↑↑↑ ↓↓
MR1-B1 IgG2a, κ ↑↑ ↑↑↑ ↓↓
MR1-G2 IgG1, κ ↓↓
MR14-E5 IgG2a, κ ↓↓
MR14-F5 IgG2a, κ
MR16-E3 IgG2a, κ ↑↑↑
  1. ↑ weak upregulation; ↑↑ medium upregulation; ↑↑↑, strong upregulation; ↓ weak downregulation; ↓↓ medium downregulation; ─ no change